The results of univariate Cox regression analysis indicated that several factors (e.g., M0 stage (p < 0.001), primary therapy outcome (PR&CR) (p = 0.006), PSA ≥4 ng/ml (p = 0.001), and FMR1 high expression (p = 0.041 < 0.05)) were negative predictor for overall survival outcome in prostate cancer patients; however, the other six genetic factors were not shown to be significant predictors for the overall survival outcome in prostate cancer patients. This evidence concerns the gene FMR1 and Familial prostate cancer.