All study subjects [80% male; 53.3% born with spontaneous delivery; 80% with familial allergy risk; mean age (±SD) at CMPA diagnosis 3 ± 2.5 months; mean age (±SD) at enrolment 16.7 ± 5.9 months, mean total serum IgE (±SD) 298.2 ± 200.4 kU/L] were from families of middle socioeconomic status and lived in urban areas. Here, IGHE is linked to allergic disease.