Ten indicators, including age, family history of thyroid tumor, history of radiation exposure, nodule size, Bethesda category, TIRADS, serum levels of TSH, TPOAb, Tg, and HDL-C, were selected as the input variables in the BPNN model, i.e., variables with statistical significance in the univariate logistic regression analyses, as well as family history of thyroid tumor and history of radiation exposure, which have notable clinical relevance. This evidence concerns the gene TG and thyroid tumor.