For example, circulating EV associated Copine III has been found to have diagnostic and prognostic significance for colorectal cancer.135 Melanoma biomarkers MIA and S100B are found on serum EVs and are predictive of diagnosis and prognosis of melanoma.136 Ascites derived EV associated E-cadherin has diagnostic utility in ovarian cancer and serum EV associated EphrinA2 may aid diagnosis of prostate cancer.137,138. This evidence concerns the gene S100B and melanoma.