Elevated levels of heterogeneous nuclear ribonucleoprotein H1 messenger RNA (mRNA) is detected in serum derived EVs of hepatocellular carcinoma patients115 and elevated human telomerase reverse transcriptase mRNA in circulating serum EVs has shown promise as a pan-cancer marker.116 RNA silencing microRNAs (miRNAs) are present in abundance inside EVs and many studies have found that miRNAs can act as diagnostic and/or prognostic indicators of several types of cancer. This evidence concerns the gene HNRNPH1 and cancer.