Concerning the main known risk factors for AD, homozygosity for APOE ε4 allele has previously been reported to be associated with a significantly increased risk of EOAD than of LOAD, regardless of family history (van Duijn et al., 1994; BLACKER et al., 1997; Cochran et al., 2019); in agreement, it reaches 7.84% in our dataset. The gene discussed is APOE; the disease is Alzheimer disease.