LYPLA2P1 and acute lymphoblastic leukemia: Wu et al. used a label-free signal-on fluorescence aptasensor based on the Tb3+–Apt as a probe to detect the T-cell acute lymphoblastic leukemia cell line (CCRF-CEM).24 CCRF-CEM could combine with the Tb3+–Apt to form a Tb3+–Apt–CEM complex and cause fluorescence changes.