When these endogenous ligands are attached to the extracellular domain of EGFR, they form heterogeneous or homologous dimmers.42These dimmers triggered tyrosine kinases, which result in autophosphorylation of tyrosine residue and afterward triggered various downstream signaling pathways like phosphatidylinositol 3-kinase/ protein kinase B(PI3K/Akt) pathway and Ras-Raf-mitogen-activated protein kinase pathway, which give rise to antiapoptosis, proliferation, metastasis, and angiogenesis of tumor cells.43 Here, AKT1 is linked to neoplasm.