Compared to control group, α-SMA, SM-MHC, and p62 were significantly downregulated, while PI3KC2A, OPN, Beclin-1, and LC3II/I ratio greatly raised by 5 g stretch stress in AD rat, which were dramatically reversed by C/EBPα knockdown (Figure 11). The gene discussed is PIK3C2A; the disease is Alzheimer disease.