Guideline recommendations for optimal medical therapy to address major CVD risk factors in patients with advanced kidney disease.23,24,25,26,27,28 BP: blood pressure; Hb: hemoglobin; HD: hemodialysis; HTN: hypertension; CKD: chronic kidney disease; DASH: Dietary Approaches to Stop Hypertension; PD: peritoneal dialysis; T2DM: type 2 diabetes mellitus; eGFR: estimated glomerular filtration rate; MI: myocardial infarction; SGLT2i: sodium/glucose cotransporter-2 inhibitors; ESAs: erythropoiesis-stimulating agents; HD: hemodialysis; PD: peritoneal dialysis; PTH: parathyroid hormone. The gene discussed is PTH; the disease is type 2 diabetes mellitus.