Glucose reabsorption via SGLT2 increases in patients with T2DM due to hyperglycemia, which results in hyperfiltration and increased luminal glucose load.30 As a result, the oxygen demand of tubular cells increases, leaving the proximal tubule relatively hypoxic.31 SGLT2i decrease the reabsorption of sodium and glucose, thus reducing proximal tubular workload and overcoming the hypoxia. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.