TMPRSS2 and Sepsis: Several pathophysiological mechanisms are involved, including renal hypoperfusion related to mechanical ventilation, hypoxemia, sepsis, systemic inflammation, and cytokine storm [35] as well as direct toxicity of the virus on proximal tubular cells and podocytes, mediated by angiotensin-converting receptor 2 (ACE 2) and transmembrane serine protease 2.