CXCR3, which is expressed on Th1, macrophage and NK cells, and its ligands (CXCL9, CXCL10) is an important chemokine axis in tumor suppression via interferon-induced cell-mediated immunity and inhibition of angiogenesis (Mantovani et al., 2004). The gene discussed is CXCL9; the disease is neoplasm.