Finally, SIRT1 activation remarkably inhibits oxidative stress [137, 138] in vascular endothelial cells [139] that are heavily involved in the pathogenesis of the cytokine storm in COVID-19, knowing that hyperinflammation-induced uncontrolled oxidative stress results in substantial endothelial cell damage [8–10, 12, 13], capillary leak and edema formation, and subsequent ARDS worsening [140]. The gene discussed is SIRT1; the disease is COVID-19.