RNLS and infection: The MAPK activation via renalase supplementation has been proven to be protective [18, 25], whereas its inhibition, which may be distinctly important during SARS-CoV-2 related infection [6], has also been confirmed [20, 33, 34, 36], and this type of response and its plausible utility in COVID-19 will be thoroughly discussed in the final section of the review.