NLRP3 and COVID-19: Namely, several viral proteins, including open-reading frame (ORF)3a and nonstructural protein (NSP)6, are directly associated with the initiation of autophagy [152], whereas autophagy seems likely to contribute to the reduction of IL-17- and NLRP3-dependent signaling [149, 153], recognized as important mechanisms in the pathophysiology of COVID-19 [112, 115].