In let-7i mimic-treated cardiomyocytes group, apoptosis-related biomarkers Annexin V and cleaved caspase 3 were decreased, the expression of Bcl2 was increased, and related biomarkers (YAP1, CTGF, and TEAD1) in the YAP signaling pathway were inhibited, and myocardial fibrosis in pathological staining is mitigated [87]. This evidence concerns the gene YAP1 and Myocardial fibrosis.