During the assessment of myocardial function and mitophagy in ALDH2 knockout (ALDH2-/-) mice, α-LA acted to restore the activity and expression of ALDH2, increase the expression level of the mitophagy receptor protein FUNDC1, and reduce TAC-induced ventricular hypertrophy and ventricular dysfunction. This evidence concerns the gene ALDH2 and Ventricular hypertrophy.