Since neonatal cholestasis has many different causes including BA, the most severe and poorest prognosis, and other non-BA cholestasis such as viral infection including CMV and herpes viruses; metabolic liver diseases or genetic disorders such as alpha-1-antitrypsin deficiency and Alagille syndrome (25). This evidence concerns the gene SERPINA1 and hyperinsulinemic hypoglycemia, familial, 4.