FGF-23 is a bone-derived hormone whose primary role is to regulate vitamin D metabolism and renal phosphate homeostasis; meanwhile, it has been reported that FGF-23 regulates the development of cardiovascular disease by motivating nitric oxide (NO) production, endothelial nitric oxide synthase (eNOS) expression, and cell proliferation in human aortic endothelial cells (9, 18). The gene discussed is NOS3; the disease is cardiovascular disorder.