Multivariate Cox's proportional hazards regression analysis exhibited that serum FGF-23 before surgery level (high vs. low) [P = 0.015, hazards ratio (HR) = 2.940], age (≥65 years vs. <65 years) (P = 0.006, HR = 3.411), diabetes (yes vs. no) (P = 0.011, HR = 2.703), previous stroke (yes vs. no) (P = 0.010, HR = 5.095), LVEF <50% (yes vs. no) (P = 0.023, HR = 2.733), and higher disease extent (P = 0.011, HR = 3.303) were all independently associated with higher cumulating MACCE rate in ULMCAD patients receiving CABG (Table 3). This evidence concerns the gene FGF23 and Stroke.