FGF-23 is a bone-derived hormone whose primary role is to regulate vitamin D metabolism and renal phosphate homeostasis; meanwhile, it has been reported that FGF-23 regulates the development of cardiovascular disease by motivating nitric oxide (NO) production, endothelial nitric oxide synthase (eNOS) expression, and cell proliferation in human aortic endothelial cells (9, 18). This evidence concerns the gene FGF23 and cardiovascular disorder.