HNF4A and liver cancer: Considering the association between the overexpression of HNF4a and reduction in cancerous phenotype of HCC cells, in the present study through a differentiation therapy approach, we investigated the effect of HNF4a induced expression in HCC cell lines after treatment with CLA, the natural ligand of HNF4a. Hep-3B as primary and Sk-Hep-1 as stromal liver cancer cell lines were assessed to show whether CLA treatment can reduce various cancerous features including proliferation rate, colony formation, and migration capacity.