PTPRD and neoplasm: In particular, the accuracy of the NAD(P)H FLIM-based stratification could solve intra-tumor heterogeneity, confirmed by the different TMZ responses of GB3 and GB4 c and p portions (Figure 4G), which according to their phenotype had differential gene expression levels for several of the genes listed above, especially ANKRD28 and PTPRD that completely lost gene expression in the TMZ NR portions (Figure 5B).