Furthermore, OIT3 promotes the ferroptosis of HCC cells by regulating the arachidonic acid metabolism and ROS accumulation, which is consistent with the previous observation suggesting that OIT3 is involved in lipid metabolism in the liver, including the triacylglycerol (TG) and very-low-density lipoproteins (VLDLs) (27). Here, OIT3 is linked to hepatocellular carcinoma.