In this study, we found that although both PNI and GGT/ALT could predict the prognosis of patients with HCC within the Milan criteria, their low accuracy and mutual exclusion as independent predictors suggest a possible combination. Therefore, the novel prognostic score model based on PNI and GGT/ALT, the PNI-GGT/ALT score is a combination of PNI as a systemic inflammation- and nutrition-related marker, and GGT/ALT is a liver inflammation-related marker that can increase the predictive values. The gene discussed is GPT; the disease is Hepatitis.