KLK3 and carcinoma: Inclusion:- Histologically confirmed prostate carcinoma with tissue classification according to Gleason score and PSA- Low- or intermediate-risk carcinoma according to d’Amico criteria or early high-risk Carcinoma (cT3a and/or GS ≤ 8 and/or PSA ≤ 20ng/ml)- IPSS (International Prostate Symptom Score) max of 12- Prostate volume <80cm3- Karnofsky index ≥ 70%- Age ≥ 18 years- Patient information provided and written consent- Ability of the patient to give consentDesign:- Prospective, non-randomized, multicenter, Phase II testing 37.5 Gy in 5 fractions- Planned accrual of 68 patients.