EZH2 and brain neoplasm: The administration of methyltransferase inhibitors in combination with PDT aid the effective release, enhancing antitumor immunity and potentiating the antitumor effects.37 The epigenetic regulator polycomb group (PcG) proteins play an important role in histone mediated epigenetic regulation which has been implicated in the malignant evolution of GBM.38 Polycomb genes (EZH2, RBBP7, SUZ12, and YY1) are specifically overexpressed in brain tumors.39 EZH2 is involved in some glioma cell processes; including proliferation, apoptosis, invasion, and angiogenesis.