ERBB2 and breast carcinoma: Gallen Consensus 2011 classified breast cancer into four molecular subtypes, luminal A (ER +/PR +/HER2 −/low Ki-67); luminal B (ER +/PR +/HER2 −/+/high Ki-67); HER2-overexpression (ER −/PR −/HER2 + ), and triple-negative breast cancers (TNBCs) (ER −/PR −/HER2 − ).9