MTOR and neoplasm: Furthermore, a study shows that hypoxic TAMS strongly upregulated the expression of Redd1 (a TOR complex 1-MTORC1 inhibitor), a negative regulator of the mechanistic target of rapamycin (mTOR, a key nutrient, and energy sensor); Metabolic changes promote tumor angiogenesis and metastasis by inhibiting the glycolysis of hypoxic TAMs, inhibiting their angiogenesis and immunosuppressive effects (107).