PPARG and melanoma: A study suggests that high levels of reactive oxygen species (ROS) in primary melanoma may increase cytokine-tumor necrosis factor-α (TNF-α) secretion through MAPK/ERK kinase 1-mediated peroxisome proliferator-activated receptor γ (PPARγ) translocation to the nucleus, and it thus enhanced the invasion of TAMs in melanoma (37).