Besides, ligand-receptor interactions such as CCL3/CCR1, CCL3/CCR5, CCL5/CCR5, CX3CL1/CX3CR1, and VEGF-A/VEGFR1 and chemokines such as CCL7, CCL8, CCL9, CCL18, CCL20, IL-13...all can contribute to the survival, progression, and metastasis of various tumor including melanoma by recruiting TAMs to TEM (40). This evidence concerns the gene CCR5 and neoplasm.