In addition, according to previous reports (25), CRS cases are more severe with the usage of CARs that employ CD28 as a costimulatory domain compared with the usage of CARs that employ 4-1BB constructs, and Tania Jain’s research showed (26) that the CAR construct was significantly associated with differences in the peak level, expansion, and persistence of various CAR-T-cells, factors that contribute to the development of cytopenias. Here, CD28 is linked to congenital rubella syndrome.