To further explore the biological functions and regulatory roles performed by CLRs in the tumor microenvironment, we performed a differential gene analysis based on TCGA data from bladder cancer tissue samples, which can be divided into two subgroups, CLR-high and CLR-low, to determine the differentially expressed genes (DEGs) potentially under the regulation of CLRs in bladder cancer (Figures 3A–D). The gene discussed is DCLK3; the disease is urinary bladder cancer.