CYP1B1 and diabetes mellitus: Although the upregulation of CYP1B1, one of the target genes of the hub DE miRNAs in BC (hsa-miR-27b), in our BC profile is not unexpected, patients with diabetes presenting high CYP1B1 expression may be more likely to develop BC, as CYP1B1 might be downregulated by hsa-miR-27b, which is expressed during BC development.