The following results were obtained from the analysis of ccRCC genomic alterations: (i) The CuAGS-13 score was significantly correlated with tumor mutation burden (TMB) in a positive manner (Figure 5B), and high-risk score tumors carried significantly a significantly higher frequency of BAP1 and SETD2 mutations (Figure 5C). This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.