They found that tumor cells (murine breast cancer 4T1, cervical carcinoma TC-1, colon carcinoma MC38-OT I, and MC38 and melanoma B16/F10 cell lines) secreted tumor-derived exosomes (TDEs), which arose the PPAR-α-mediated reaction in DCs; in the meantime, PPAR-α also undertook the role of transporting TDEs into DCs. Here, PPARA is linked to neoplasm.