A total of 60 positively correlated KEGG and HALLMARK pathways were obtained (FDR<0.25, p<0.05, |NES| >1), including melanoma, TGF-β signaling pathway, IL6-JAK-STAT3 signaling pathway, KRAS signaling up, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, apoptosis, angiogenesis and hypoxia (Figure 3D). This evidence concerns the gene KRAS and melanoma.