ROS can lead to NFκB activation, cell apoptosis, protein modification, and oxidative damage to other biomolecules.4,5 ROS also disrupts redox dependent signaling in the vessel wall to promote progress of atherosclerosis,6,7 involving signal transduction pathways,8 regulatory genes associated with vascular function,7 inflammatory components of atherosclerosis,9 and clearance of apoptotic cells by macrophages.10 This evidence concerns the gene NFKB1 and atherosclerosis.