NPM1 and acute myeloid leukemia: For this reason, it is interesting that the Cancer Genome Atlas (TCGA) reported that AML cells have a low average mutation frequency (approximately 1 mutation per megabase), these being mainly C > T transitions and affecting genes such as PIK3CA, IDH1, IDH2, NPM1, FLT3, RUNX1, MIR142, DNMT3A, TET2, GATA3 and MAP3K1 where on average two non‐synonymous mutations occur.34