Additionally, although GM2A and AD brain extract (ALB01) did not reduce the overall protein expression level of presynaptic VGLUT2 (vesicular-glutamate transporter 2) or HOMER1 (homer protein homolog 1), a postsynaptic density scaffold protein (Supplemental Fig. 3A-G) in protein lysates, they did reduce the number of puncta with co-localization of VGLUT2 and HOMER1 in neurites (Supplemental Fig. 3H-L), indicating a potential impact of elevated GM2A on synaptic number in cultured neurons. This evidence concerns the gene SLC17A6 and Alzheimer disease.