In addition to genomic variation, the gene regulatory network with TFs as pivots was organized into six modules (Fig. 3E), such as BCL6, FOXO1, E2F7, and FOXP2, to regulate the specific gene expression (Fig. 3F) and RNA transcription rate (Fig. 3G) of MM malignant cell subpopulations to guide cellular fate choice. This evidence concerns the gene BCL6 and Miyoshi myopathy.