Three mRNAs (Notch1, Grb2, and IL-4) and four lncRNAs (BC089934, EF076772, BC092620, and BC088302) may be promising targets for accelerating liver regeneration before or after extensive hepatectomy, as revealed by liver tissue microarray and WGCNA analysis in PVL animals and validated by liver tissue samples from PVE clinical patients. This evidence concerns the gene IL4 and periventricular leukomalacia.