In the current study, the results from GO analysis revealed that IL-6 production (Cd24, Aqp4, Sirpa Adora2b, Gas6, Nod2, and Myd88, etc.), together with classical Wnt signaling pathway (Fgfr2, Gpc3, Notch1, Fzd6, and Hdac2, etc.)and acute inflammatory response (C4pbpa, Ptger3, Cd46, Masp1, and Serping1, etc.)were immediately upregulated after PVL and remain high up to day 14 post-PVL. Here, HDAC2 is linked to periventricular leukomalacia.