Overall, these data indicate that blockade of PGK1 or ALDOA using FANA oligonucleotides restores the response of Th17 cells derived from Crohn’s disease patients to UCB; this is reflected by higher levels of CD39, FOXP3, and IL-10, increased proportions of CD39+ cells and heightened frequencies of FOXP3+ and IL-10+ lymphocytes within polarized Th17 cells. Here, IL10 is linked to Crohn disease.