Compared to scramble, the addition of UCB and FANA-PGK1 or FANA-ALDOA boosted the levels of ENTPD1 (encoding for CD39), FOXP3, and IL10 in both controls and patients (Fig. 5a–c), whereas the addition of UCB alone increased ENTPD1, FOXP3 and IL10 expression in controls (Fig. 5a–c) and boosted FOXP3 levels in Th17 cells derived from Crohn’s disease patients (Fig. 5b). This evidence concerns the gene IL10 and Crohn disease.