In other cancer types, including glioma and HCC, LBX2-AS1 affects cell proliferation and apoptosis through the miR-491-5p-leukemia inhibitory factor (LIF)-signal transducer and activator of transcription 3 (STAT3) and miR-384-insulin receptor substrate 1 (IRS1) pathways, respectively [32, 52]. This evidence concerns the gene IRS1 and central nervous system cancer.