GSK3B and cancer: Over the past decades, dual luciferase reporter and gain- and loss-of-function assays have revealed that LBX2-AS1 is capable of regulating the AKT-glycogen synthase kinase-3 beta (GSK3β) and Notch pathways [53, 77], which play crucial functions in enhancing cancer cell motility and contribute to cancer metastasis [78–81].