GNAI3 is also present in two other significantly dysregulated networks in monocytes—Cushing Syndrome and cAMP signaling—but does not have a high importance score in those networks, indicating that it is critical in regulating signal coming from CXCR4 only in the leukocyte transendothelial migration network. The gene discussed is CXCR4; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.