PDGFRA and schizophrenia: Increased expression of DISC1-Δ3 variant in the newly generated transgenic mouse strain replicated the OPC hypertrophy in schizophrenia patients, as shown by the enlarged PDGFRα (increased by 91.6 ± 16.5%) (Fig. 2d, Supplementary Fig. 2h) and NG2CreERT:tdTomato labeling areas per cell (increased by 32.4 ± 8.5%) (Fig. 2e), with a more hypertrophic morphology (Fig. 2f).