Consistent with our findings in DISC1-Δ3 mice, WIF1 intensity was significantly increased by 111.4 ± 34.5% in the hippocampus of schizophrenia patients when compared to that in the age-matched healthy controls (Fig. 5j), which is in agreement with previous observations that WIF1 is altered in schizophrenia postmortem brains [43, 44]. This evidence concerns the gene DISC1 and schizophrenia.