At postnatal day (P)25 to P36, the age of mice approximately corresponding to human adolescence (12–18 years old) when the first episode of schizophrenia usually occurs [1, 29], enhanced oligodendroglial DISC1-Δ3 splicing resulted in schizophrenia-like sensorimotor gating impairment as reflected by the prepulse inhibition test (Fig. 2g), as well as by the positive symptoms [30] in the open field test and cliff avoidance test (Fig. 2h, i). The gene discussed is DISC1; the disease is schizophrenia.