DISC1 and schizophrenia: In order to further confirm that aberrant OPCs but not mature OLs contribute to the neuronal defects during the onset of schizophrenia, we cross-bred the DISC1exon3 flox mice with the OL-specific PLPCreERT mice to obtain PLPCreERT:DISC1exon3 fl/+ mice (OL DISC1-Δ3, Fig. 4g).