The infection specificity for oligodendroglial cells was validated by co-labeling of GFP+ with NG2creERT:tdTomato+ (82.13 ± 1.45%) and PDGFRα+ (45.19 ± 1.11%), but rarely with the markers of neurons (5.03 ± 0.38%), microglial cells (5.44 ± 0.67%), astrocytes (0.69 ± 0.69%), and pericytes (1.33 ± 0.67%) (Supplementary Fig. 6a), which is consistent with previous observations [51]. Here, PDGFRA is linked to infection.