DISC1 and schizophrenia: However, recent advances showed that DISC1 dysfunction also affects OPC maturation and subsequent myelination [19, 20], while RNA-sequencing analyses in both humans and mice demonstrated that OPCs express higher levels of DISC1 when compared to neurons or mature oligodendrocytes (OLs) [21, 22], raising a possibility that the high presence of DISC1 in the OPCs may contribute to the pathogenesis of schizophrenia.