Although we still lack direct evidence linking OPC hypertrophies to Wnt-signaling hyperactivation, as well as their association with DISC1-Δ3 splicing in schizophrenia patients, these early changes in OPCs, (found in both schizophrenia patients and mouse model), may either initiate or contribute to the onset of schizophrenia. This evidence concerns the gene DISC1 and schizophrenia.