Notably, in DNMT3A, variants at the p.R882 hotspot codon were less common in CH (4/87 DNMT3A mutations, 5%) compared to MDS (9/28, 32%) and sAML (14/37, 38%) (p < 0.001) (Fig. 7), suggesting that codon p.R882 mutations associate with disease progression and may have different functional implications compared to other variants in the gene. Here, DNMT3A is linked to myelodysplastic syndrome.