ITGAM and colorectal carcinoma: Furthermore, the phagocytic activity of macrophages was assessed on A3373-treated CFSE-labeled CRC cells cocultured with phorbol 12-myristate 13-acetate (PMA)-activated THP1 macrophages, which showed that A3373 significantly increased the population of CD11b+CFSE+ macrophages compared to that in vehicle-treated cells (Fig. 5g).