According to20, there was a correlation between relapse of Graves' disease and CC genotype of TSHR gene on the rs2268458 of intron 120. In a study, related to thyroid disease association with polymorphism in Iraq, 73 cases were homozygote (TT), 20 cases were heterozygotes (TC) and 1 case was homozygote (CC) and since all the research was done on females, the homozygote (CC) case was a woman13 but in this study, both men and females were involved and the homozygote case (CC) was a man. This evidence concerns the gene TSHR and thyroid gland disorder.