xCT, a functional subunit of the cystine/glutamate antiport (system Xc-), Hasegawa et al. found that the inhibition of mucin 1 (MUC1)/xCT signaling pathway can induce GSH level imbalance and ROS-mediated ferroptosis in TNBC cells, resulting in killing tumor cells and reducing their self-renewal ability [10]. The gene discussed is SLC7A11; the disease is neoplasm.