ITGB3 and neoplasm: In line with the result of docking model, GST-MIIP could pulldown ITGB3, but not ITGAV, the predominant counterpart of ITGB3 in tumor cells, indicating the direct interaction between MIIP and ITGB3 (Fig. 5B), which is consistent with the reports that β3 integrin contains the RGD ligand-binding site and RGD motif binds primarily to the β subunit of ITGAvB3 integrin [25, 28].