These results revealed not only the essentiality of SNHG1 in NB growth, but also the application of this cell model for investigating the molecular mechanisms of SNHG1. Transcriptomics analysis of SNHG1-depletion cells with corresponding functional assays demonstrated the suppression of SNHG1 affects various biological processes in NB cells, consistent with previous works [12]. The gene discussed is SNHG1; the disease is neuroblastoma.