The SK-N-BE(2)C cell line belongs to the ADRN subtype of NB, and the transcriptional CRC, composed of MYCN, HAND2, ISL1, PHOX2B, GATA3, and TBX2, enables to maintain the cell state of the ADRN subtype of NB [21]. This evidence concerns the gene HAND2 and neuroblastoma.