Regarding the more common ATN profiles, our findings were similar to previous reports, e.g., older age, a higher percentage of APOE ε4 carriers, and poorer cognition among A+T+ vs A−T−N−,9,15,20 and a higher prevalence of vascular pathology and comorbidity in non-AD pathologic change (alone or concomitant with AD).15 This evidence concerns the gene APOE and Alzheimer disease.