Through comprehensive cardiovascular MR (CMR), we are also assessing circumferential peak early diastolic strain rate, a sensitive measure22 with excellent test–retest reproducibility28; end-diastolic mass to volume ratio, a marker of concentric left ventricular remodelling29; and measures of aortic distensibility, a key determinant of concentric remodelling in T2DM.29 We will also ascertain impacts on a range of other measures (table 1) of insulin resistance, fitness, adiposity, cardiorenal parameters, diet, physical activity, mood and quality of life. Here, INS is linked to type 2 diabetes mellitus.