Notably, two genes that differ in expression between MacSPP1 and CD14CTX are related to chemotaxis and extravasation (SERPINB2 [Schroder et al., 2019], TIMP1 [Roeb et al., 2005]), suggesting a transition in macrophages that have already migrated to the tumor microenvironment. Here, SERPINB2 is linked to neoplasm.