With a firm connection established between EGFR signaling and AMPK activity in GBM tissue and across multiple cell lines, we turned our attention to the question of how AMPK signaling may in turn influence regulation of the mutant TERTp. The PRKAB1 subunit of the AMPK complex is overexpressed in GBM and is essential for kinase activity of AMPK and downstream signaling in GBM (Chhipa et al., 2018). The gene discussed is PRKAB1; the disease is glioblastoma.